anti-CKMT1A antibody [17A2]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [17A2] recognizes CKMT1A
  • 反应物种: Hu
  • 应用: FACS, WB
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: 17A2
  • 同位型: IgG2b, kappa
  • 靶点名称: CKMT1A
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG57033
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Product Details
概述
产品描述Mouse Monoclonal antibody [17A2] recognizes CKMT1A
反应物种Hu
应用FACS, WB
宿主Mouse
克隆Monoclonal
克隆号17A2
同位型IgG2b, kappa
靶点名称CKMT1A
抗原物种Human
抗原Recombinant fragment around aa. 40-417 of Human CKMT1A.
偶联标记Un-conjugated
別名CKMT1; U-MtCK; mia-CK
应用说明
应用建议
应用推荐稀释比
FACSAssay-dependent
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein A.
缓冲液PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂10% Glycerol
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 548596 Human CKMT1A

Swiss-port # P12532 Human Creatine kinase U-type, mitochondrial

基因名称CKMT1A
全名creatine kinase, mitochondrial 1A
背景介绍Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]
生物功能Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. [UniProt]
预测分子量47 kDa
检测图片 (2)
  • ARG57033 anti-CKMT1A antibody [17A2] FACS image

    Flow Cytometry: HeLa cell line stained with ARG57033 anti-CKMT1A antibody [17A2] at 2-5 µg for 1x10^6 cells (red line). Secondary antibody: Goat anti-Mouse IgG Alexa fluor 488 conjugate. Isotype control antibody was Mouse IgG (black line).

  • ARG57033 anti-CKMT1A antibody [17A2] WB image

    Western blot: 40 µg of 1) 293T cell lysate, and 2) HeLa cell lysate stained with ARG57033 anti-CKMT1A antibody [17A2] at 1:1000.

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