anti-CLN5 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG58407
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CLN5 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CLN5 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 96-407 of Human CLN5 (NP_006484.1). |
| 偶联标记 | Un-conjugated |
| 別名 | NCL; Protein CLN5; Ceroid-lipofuscinosis neuronal protein 5 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse heart | ||||||
| 实际分子量 | 50 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # O75503 Human Ceroid-lipofuscinosis neuronal protein 5 Swiss-port # Q3UMW8 Mouse Ceroid-lipofuscinosis neuronal protein 5 homolog |
|---|---|
| 基因名称 | CLN5 |
| 全名 | ceroid-lipofuscinosis, neuronal 5 |
| 背景介绍 | This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.[provided by RefSeq, Oct 2008] |
| 细胞定位 | Lysosome. [UniProt] |
| 预测分子量 | 41 kDa |
| 翻译后修饰 | N-glycosylated with both high mannose and complex type sugars. Glycosylation is important for proper folding and trafficking to the lysosomes. Ceroid-lipofuscinosis neuronal protein 5: The type II membrane signal anchor is proteolytically cleaved to produce a mature form that is transported to the lysosomes (Ceroid-lipofuscinosis neuronal protein 5, secreted form) (PubMed:24038957, PubMed:20052765). Can undergo proteolytic cleavage at the C-terminus, probably by a cysteine protease and may involve the removal of approximately 10-15 residues from the C-terminal end (PubMed:26342652). [UniProt] |
检测图片 (1)
ARG58407 anti-CLN5 antibody WB image
Western blot: 25 µg of Mouse heart lysate stained with ARG58407 anti-CLN5 antibody at 1:3000 dilution.
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