anti-CMBL antibody [2B11]
![anti-CMBL antibody [2B11]](/upload/image/products/ARG57007_WB_1_210_205.jpg)
![anti-CMBL antibody [2B11]](/upload/image/products/ARG57007_WB_1.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
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- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG57007
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [2B11] recognizes CMBL |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 2B11 |
| 同位型 | IgG2a, kappa |
| 靶点名称 | CMBL |
| 抗原物种 | Human |
| 抗原 | Recombinant fragment around aa. 1-245 of Human CMBL. |
| 偶联标记 | Un-conjugated |
| 別名 | JS-1; Carboxymethylenebutenolidase homolog; EC 3.1.-.- |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 10% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q96DG6 Human Carboxymethylenebutenolidase homolog |
|---|---|
| 基因名称 | CMBL |
| 全名 | carboxymethylenebutenolidase homolog (Pseudomonas) |
| 背景介绍 | CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010] |
| 生物功能 | Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. [UniProt] |
| 预测分子量 | 28 kDa |
检测图片 (1)
ARG57007 anti-CMBL antibody [2B11] WB image
Western blot: 40 µg of HeLa cell lysate stained with ARG57007 anti-CMBL antibody [2B11] at 1) 1:500, 2) 1:1000, and 3) 1:5000 dilution.
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