anti-Collagen IV antibody
Key features and details
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CAT.NO. : ARG23197
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Collagen IV Rabbit anti Human collagen IV antibodyrecogizes human collagen IV, also known as Collagen alpha-1(IV) chain. Collagen IV is a 1497 amino acid structural extracellular matrix protein and key component of the glomerular basement membrane. Arresten, comprising the c-terminal 225 amino acids of collagen IV demonstrates potent anti tumorigenic and anti angiogenic proterties (Nyberg et al. 2008). Rabbit anti Human collagen IV antibody exhibits the following reactivities with Collagen IV and related proteins:Human collagen IV100%Human types I, III and V |
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| 反应物种 | Hu |
| 应用 | ELISA, ICC/IF, IHC-Fr, IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Collagen IV |
| 抗原物种 | Human |
| 抗原 | Collagen IV from Human placenta. |
| 偶联标记 | Un-conjugated |
| 別名 | CA44; Collagen alpha-4(IV) chain |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Pretreatment is required with 1 mg/ml pepsin in 0.5 M acetic acid for two hours at 37°C and multiple buffer washes. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, salts, Dextran and Mannitol. |
| 稳定剂 | Dextran and Mannitol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | COL4A4 |
| 全名 | collagen, type IV, alpha 4 |
| 背景介绍 | This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR. [provided by RefSeq, Jul 2008] |
| 生物功能 | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. [UniProt] |
| 预测分子量 | 164 kDa |
| 翻译后修饰 | Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues. [UniProt] |
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