anti-Collagen IV antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原:
- 偶联标记:
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Brand:
CAT.NO. : ARG67143
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Collagen IV |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Collagen IV |
| 抗原 | Synthetic peptide |
| 偶联标记 | Un-conjugated |
| 別名 | COL4A1; Collagen Type IV Alpha 1 Chain; Collagen Alpha-1(IV) Chain; Collagen Of Basement Membrane, Alpha-1 Chain; Collagen IV, Alpha-1 Polypeptide; Collagen, Type IV, Alpha 1; COL4A1 NC1 Domain; EC 6.3.1.2; EC 3.4.23; Arresten; COL4A1s; PADMAL; BSVD1; RATOR; BSVD |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | 100 mM Tris Glycine (pH 7.0), 0.025% ProClin 300 and 20% Glycerol. |
| 抗菌剂 | 0.025% ProClin 300 |
| 稳定剂 | 20% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | COL4A1 |
| 全名 | Collagen Type IV Alpha 1 Chain |
| 背景介绍 | This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| 生物功能 | Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. [UniProt] |
| 细胞定位 | Basement membrane, Extracellular matrix, Secreted. [UniProt] |
| 研究领域 | Angiogenesis Study antibody; Basement Membrane Marker antibody |
| 预测分子量 | 161 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Hydroxylation. [UniProt] |
检测图片 (3)
ARG67143 anti-Collagen IVantibody IHC-P image
Immunohistochemistry: Human placenta stained with ARG67143 anti-Collagen IVantibody at 1:100 dilution.
ARG67143 anti-Collagen IVantibody WB image
Western blot: Human placenta stained with ARG67143 anti-Collagen IVantibody.
ARG67143 anti-Collagen IVantibody IHC-P image
Immunohistochemistry: Mouse liver stained with ARG67143 anti-Collagen IVantibody at 1:100 dilution.
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