anti-Collagen VII antibody [LH7.2]

产品描述: Mouse Monoclonal antibody [LH7.2] recognizes Collagen VIIMouse anti Human collagen VII antibody, clone LH7.2 recognizes the carboxy-terminus of type VII collagen (Kirkham et al. 1989). Collagen VII is a basement membrane protein in stratified squamous epithelia which is involved in membrane organization through interaction with other ECM components (Gammon et al. 1992). It is composed of three identical alpha chains, each having an amino-terminal non-collagenous domain and a carboxy-terminal collagenous domain.Mouse anti Human collagen VII, clone LH7.2 has proved effective for immunohistochemical identification of basement membrane in human skin (Watson et al. 2001).
反应物种: Hu
不反应物种: Ms, Rat, Pig
应用: IHC-Fr
宿主: Mouse
克隆: Monoclonal
克隆号: LH7.2
同位型: IgG1
靶点名称: Collagen VII

CAT.NO. : ARG23074

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Size:

50 μg

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Mouse Monoclonal antibody [LH7.2] recognizes Collagen VII Mouse anti Human collagen VII antibody, clone LH7.2 recognizes the carboxy-terminus of type VII collagen (Kirkham et al. 1989). Collagen VII is a basement membrane protein in stratified squamous epithelia which is involved in membrane organization through interaction with other ECM components (Gammon et al. 1992). It is composed of three identical alpha chains, each having an amino-terminal non-collagenous domain and a carboxy-terminal collagenous domain.Mouse anti Human collagen VII, clone LH7.2 has proved effective for immunohistochemical identification of basement membrane in human skin (Watson et al. 2001).
反应物种	Hu
不反应物种	Ms, Rat, Pig
应用	IHC-Fr
宿主	Mouse
克隆	Monoclonal
克隆号	LH7.2
同位型	IgG1
靶点名称	Collagen VII
抗原物种	Human
抗原	Crude extract of skin
偶联标记	Un-conjugated
別名	EBD1; EBR1; EBDCT; NDNC8; Collagen alpha-1(VII) chain; Long-chain collagen; LC collagen

应用说明

应用建议

应用	推荐稀释比
IHC-Fr	1:25 - 1:100

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purification with Protein A.
缓冲液	PBS and 0.09% Sodium azide
抗菌剂	0.09% Sodium azide
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 1294 Human COL7A1 Swiss-port # Q02388 Human Collagen alpha-1(VII) chain
基因名称	COL7A1
全名	collagen, type VII, alpha 1
背景介绍	This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008]
生物功能	Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. [UniProt]
预测分子量	295 kDa
翻译后修饰	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

检测图片 (1)

ARG23074 anti-Collagen VII antibody [LH7.2] IHC-Fr image
Immunohistochemistry: Human ileum cryosection stained with ARG23074 anti-Collagen VII antibody [LH7.2].

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