anti-Complement C8 antibody [056B-373]

产品描述: Mouse Monoclonal antibody [056B-373] recognizes Complement C8.Mouse anti Human C8 antibody, clone 056B-373 recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane.Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
反应物种: Hu
应用: ELISA, FACS, IHC-Fr, WB
宿主: Mouse
克隆: Monoclonal
克隆号: 056B-373
同位型: IgG1
靶点名称: Complement C8
抗原物种: Human

CAT.NO. : ARG23545

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Size:

50 μg

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Mouse Monoclonal antibody [056B-373] recognizes Complement C8. Mouse anti Human C8 antibody, clone 056B-373 recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane.Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
反应物种	Hu
应用	ELISA, FACS, IHC-Fr, WB
宿主	Mouse
克隆	Monoclonal
克隆号	056B-373
同位型	IgG1
靶点名称	Complement C8
抗原物种	Human
抗原	Purified Human Complement C8.
偶联标记	Un-conjugated
別名	C8C; Complement component C8 gamma chain

应用说明

应用建议

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purification with Protein A.
缓冲液	BBS and 0.1% Sodium azide.
抗菌剂	0.1% Sodium azide
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 733 Human C8G Swiss-port # P07360 Human Complement component C8 gamma chain
基因名称	C8G
全名	complement component 8, gamma polypeptide
背景介绍	The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]
生物功能	C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. [UniProt]
预测分子量	22 kDa

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