anti-COPS5 / JAB1 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes COPS5 / JAB1
  • 反应物种: Hu, Ms, Rat
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: COPS5 / JAB1
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 1-334 of Human COPS5 (NP_006828.2).
  • Brand:
CAT.NO. : ARG59767
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes COPS5 / JAB1
反应物种Hu, Ms, Rat
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称COPS5 / JAB1
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 1-334 of Human COPS5 (NP_006828.2).
偶联标记Un-conjugated
別名MOV-34; Jun activation domain-binding protein 1; EC 3.4.-.-; JAB1; Signalosome subunit 5; SGN5; COP9 signalosome complex subunit 5; CSN5
应用说明
应用建议
应用推荐稀释比
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照PC-12, NIH/3T3 and HeLa
实际分子量37 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 10987 Human COPS5

GeneID: 26754 Mouse COPS5

Swiss-port # O35864 Mouse COP9 signalosome complex subunit 5

Swiss-port # Q92905 Human COP9 signalosome complex subunit 5

基因名称COPS5
全名COP9 signalosome subunit 5
背景介绍The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
生物功能Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. [UniProt]
细胞定位Cytoplasm, cytosol. Nucleus. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Nuclear localization is diminished in the presence of IFIT3. [UniProt]
预测分子量38 kDa
检测图片 (2)
  • ARG59767 anti-COPS5 / JAB1 antibody WB image

    Western blot: 25 µg of PC-12, NIH/3T3 and HeLa cell lysates stained with ARG59767 anti-COPS5 / JAB1 antibody at 1:1000 dilution.

  • ARG59767 anti-COPS5 / JAB1 antibody WB image

    Western blot: 25 µg of PC-12, NIH/3T3 and HeLa cell lysates stained with ARG59767 anti-COPS5 / JAB1 antibody at 1:1000 dilution through one-step method.

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