anti-COPS8 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes COPS8
  • 反应物种: Hu, Ms, Rat
  • 应用: ICC/IF, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: COPS8
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 1-209 of Human COPS8 (NP_006701.1).
  • Brand:
CAT.NO. : ARG42903
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes COPS8
反应物种Hu, Ms, Rat
应用ICC/IF, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称COPS8
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 1-209 of Human COPS8 (NP_006701.1).
偶联标记Un-conjugated
別名SGN8; COP9 signalosome complex subunit 8; Signalosome subunit 8; COP9 homolog; hCOP9; JAB1-containing signalosome subunit 8; COP9; CSN8
应用说明
应用建议
应用推荐稀释比
ICC/IF1:50 - 1:200
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照HeLa
实际分子量~ 21 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 108679 Mouse COPS8

GeneID: 10920 Human COPS8

GeneID: 363283 Rat COPS8

基因名称COPS8
全名COP9 signalosome subunit 8
背景介绍The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
生物功能Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. [UniProt]
细胞定位Cytoplasm. Nucleus. [UniProt]
预测分子量23 kDa
检测图片 (2)
  • ARG42903 anti-COPS8 antibody ICC/IF image

    Immunofluorescence: L929 cells stained with ARG42903 anti-COPS8 antibody at 1:100 dilution.

  • ARG42903 anti-COPS8 antibody WB image

    Western blot: 25 µg of HeLa cell lysate stained with ARG42903 anti-COPS8 antibody at 1:3000 dilution.

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