anti-CRH / Corticotropin Releasing Factor antibody [4H9]
![anti-CRH / Corticotropin Releasing Factor antibody [4H9]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG24101
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [4H9] recognizes CRH / Corticotropin Releasing Factor |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, ICC/IF, IHC-Fr, IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 4H9 |
| 同位型 | IgG1 |
| 靶点名称 | CRH / Corticotropin Releasing Factor |
| 抗原物种 | Human |
| 抗原 | BSA conjugated full-length Human CRH / Corticotropin-Releasing Factor protein. |
| 抗原表位 | The unique lysine residue (Lys-36) is likely to be involved in the antigenic determinant as lysine modification by CA blocks binding completely. Human serum, containing CRH / Corticotropin Releasing Factor (CRF)-binding protein, also inhibits the binding of this antibody to CRH / Corticotropin Releasing Factor (CRF). |
| 偶联标记 | Un-conjugated |
| Protein Full name | Corticoliberin |
| 別名 | CRH; Corticoliberin; Corticotropin-releasing hormone; CRF; CRH1; Corticotropin-releasing factor |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Boil tissue section in Sodium citrate buffer (pH 6.0) or enzyme digestion with 0.1% trypsin. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.1% Sodium azide. |
| 抗菌剂 | 0.1% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CRH |
| 全名 | corticotropin releasing hormone |
| 背景介绍 | Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010] |
| 生物功能 | This hormone from hypothalamus regulates the release of corticotropin from pituitary gland. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 21.4 kDa |
| 翻译后修饰 | Amidation, Cleavage on pair of basic residues |
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