anti-CSF1R antibody [SP211]

Key features and details

产品描述: Rabbit Monoclonal antibody [SP211] recognizes CSF1R
反应物种: Hu
应用: IHC-P
宿主: Rabbit
克隆: Monoclonal
克隆号: SP211
同位型: IgG
靶点名称: CSF1R
抗原物种: Human

Brand:

CAT.NO. : ARG52907

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Size:

100 μl 50 μl

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*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Rabbit Monoclonal antibody [SP211] recognizes CSF1R
反应物种	Hu
应用	IHC-P
宿主	Rabbit
克隆	Monoclonal
克隆号	SP211
同位型	IgG
靶点名称	CSF1R
抗原物种	Human
抗原	Synthetic peptide from human CSF-1R protein.
偶联标记	Un-conjugated
別名	CSF-1 receptor; CSF-1-R; FIM2; Macrophage colony-stimulating factor 1 receptor; Proto-oncogene c-Fms; CD115; CD antigen CD115; M-CSF-R; FMS; CSFR; C-FMS; EC 2.7.10.1; CSF-1R; HDLS

应用说明

应用建议

应用	推荐稀释比
IHC-P	1:100

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

阳性对照

Tonsil

属性

形式	Liquid
纯化	Purified by protein A/G
缓冲液	PBS (pH 7.6), 1% BSA and
抗菌剂
稳定剂	1% BSA
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 1436 Human CSF1R Swiss-port # P07333 Human Macrophage colony-stimulating factor 1 receptor
背景介绍	Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor and CD115, is a cell-surface tyrosine-protein kinase receptor for colony stimulating factor 1 (CSF1) and IL-34. It is expressed by monocytes and its progenitor or derived cells.It plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes. It is up-regulated in some human tumors such as carcinoma of ovary and breast.
细胞定位	Cytoplasm, Membrane, Nucleus (cleaved form)
研究领域	Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody
预测分子量	108 kDa
翻译后修饰	Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-561 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-561 and Tyr-809 is important for interaction with SRC family members, including FYN, YES1 and SRC, and for subsequent activation of these protein kinases. Phosphorylation at Tyr-699 and Tyr-923 is important for interaction with GRB2. Phosphorylation at Tyr-723 is important for interaction with PIK3R1. Phosphorylation at Tyr-708 is important for normal receptor degradation. Phosphorylation at Tyr-723 and Tyr-809 is important for interaction with PLCG2. Phosphorylation at Tyr-969 is important for interaction with CBL. Dephosphorylation by PTPN2 negatively regulates downstream signaling and macrophage differentiation. Ubiquitinated. Becomes rapidly polyubiquitinated after autophosphorylation, leading to its degradation.

检测图片 (6)

ARG52907 anti-CSF1R antibody [SP211] IHC-P image
Immunohistochemistry: Human Tonsil stained with ARG52907 anti-CSF1R antibody [SP211].
ARG52907 anti-CSF1R antibody [SP211] IHC-P image
Immunohistochemistry: Human Skin stained with ARG52907 anti-CSF1R antibody [SP211].
ARG52907 anti-CSF1R antibody [SP211] IHC-P image
Immunohistochemistry: Human Skin Squamous Cell Carcinoma stained with ARG52907 anti-CSF1R antibody [SP211].
ARG52907 anti-CSF1R antibody [SP211] IHC-P image
Immunohistochemistry: Human Colon stained with ARG52907 anti-CSF1R antibody [SP211].
ARG52907 anti-CSF1R antibody [SP211] IHC-P image
Immunohistochemistry: Human lung stained with ARG52907 anti-CSF1R antibody [SP211].
ARG52907 anti-CSF1R antibody [SP211] IHC-P image
Immunohistochemistry: Human liver stained with ARG52907 anti-CSF1R antibody [SP211].