anti-CSK antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG63445
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Product Details
概述
| 产品描述 | Goat Polyclonal antibody recognizes CSK |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Cow, Dog |
| 应用 | WB |
| 特异性 | Reported variants represent identical protein: NP_004374.1; NP_001120662.1. |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CSK |
| 抗原物种 | Human |
| 抗原 | C-EQLEHIKTHELHL |
| 偶联标记 | Un-conjugated |
| 別名 | Protein-tyrosine kinase CYL; C-Src kinase; Tyrosine-protein kinase CSK; EC 2.7.10.2 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CSK |
| 全名 | c-src tyrosine kinase |
| 生物功能 | Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. [UniProt] |
| 研究领域 | Signaling Transduction antibody; Src Family Protein Tyrosine Kinases antibody |
| 预测分子量 | 51 kDa |
| 翻译后修饰 | Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated. |
检测图片 (2)
ARG63445 anti-CSK antibody WB image
Western Blot: Mouse Spleen lysate (35 µg protein in RIPA buffer) stained with ARG63445 anti-CSK antibody at 1 µg/ml dilution.
ARG63445 anti-CSK antibody WB image
Western Blot: Jurkat lysate (35µg protein in RIPA buffer) stained with ARG63445 anti-CSK antibody (0.5µg/ml)
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