anti-CST3 / Cystatin C antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG54134
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody recognizes CST3 / Cystatin C |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | CST3 / Cystatin C |
| 抗原物种 | Human |
| 抗原 | Recombinant human cystatin c protein. |
| 偶联标记 | Un-conjugated |
| 別名 | Cystatin-C; Neuroendocrine basic polypeptide; Post-gamma-globulin; ARMD11; Cystatin-3; Gamma-trace |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | Sandwich ELISA (Capture antibody - Detection antibody): ARG54134 (4 µg/ml) - ARG54135 (0.5 µg/ml) * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | 13 kDa |
属性
| 形式 | Liquid |
|---|---|
| 浓度 | 3 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CST3 |
| 全名 | cystatin C |
| 背景介绍 | Cystatin C or cystatin 3 (formerly gamma trace, post-gamma-globulin or neuroendocrine basic polypeptide), a protein encoded by the CST3 gene,is mainly used as a biomarker of kidney function. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid (a specific type of protein deposition), such as Alzheimer´s disease. In humans, all cells with a nucleus (cell core containing the DNA) produce cystatin C as a chain of 120 amino acids. It is found in virtually all tissues and body fluids. It is a potent inhibitor of lysosomal proteinases (enzymes from a special subunit of the cell that break down proteins) and probably one of the most important extracellular inhibitors of cysteine proteases (it prevents the breakdown of proteins outside the cell by a specific type of protein degrading enzymes). Cystatin C belongs to the type 2 cystatin gene family. |
| 生物功能 | As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Cell Death antibody; Controls and Markers antibody; Developmental Biology antibody |
| 预测分子量 | 16 kDa |
| 翻译后修饰 | The Thr-25 variant is O-glycosylated with a core 1 or possibly core 8 glycan. The signal peptide of the O-glycosylated Thr-25 variant is cleaved between Ala-20 and Val-21. |
检测图片 (1)
ARG54134 anti-CST3 / Cystatin C antibody ELISA image
Standard Curve: Capture antibody: ARG54134 anti-CST3 / Cystatin C antibody at 4 µg/ml; Detector antibody: ARG54135 anti-CST3 / Cystatin C antibody at 0.5 µg/ml. These products result of a typical standard run with optical density reading at 450 nm.
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