anti-CYP11A1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG43124
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CYP11A1 |
|---|---|
| 反应物种 | Ms, Rat |
| 预测物种 | Bov |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CYP11A1 |
| 抗原物种 | Mouse |
| 抗原 | Synthetic peptide corresponding to aa. 53-66 of Mouse CYP11A1. (DNGWLNLYHFWRES) |
| 偶联标记 | Un-conjugated |
| 別名 | CYP11A; Cytochrome P450; Cholesterol desmolase; P450SCC; EC 1.14.15.6; CYPXIA1; Cytochrome P450 11A1; scc; Cholesterol side-chain cleavage enzyme, mitochondrial |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | ~ 56 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Immunogen affinity purified. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Thimerosal and 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P14137 Rat Cholesterol side-chain cleavage enzyme, mitochondrial Swiss-port # Q9QZ82 Mouse Cholesterol side-chain cleavage enzyme, mitochondrial |
|---|---|
| 基因名称 | CYP11A1 |
| 全名 | cytochrome P450, family 11, subfamily A, polypeptide 1 |
| 背景介绍 | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008] |
| 生物功能 | A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (PubMed:21636783). Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (PubMed:21636783). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:21636783). [UniProt] |
| 细胞定位 | Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes to the matrix side of the mitochondrion inner membrane. [UniProt] |
| 预测分子量 | 60 kDa |
检测图片 (1)
ARG43124 anti-CYP11A1 antibody WB image
Western blot: 50 µg of Rat testis, Mouse testis and Mouse brain lysates stained with ARG43124 anti-CYP11A1 antibody at 0.5 µg/ml dilution.
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