anti-CYP3A4 antibody

CAT.NO. : ARG44590

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Size:

100 μl

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Rabbit Polyclonal antibody recognizes CYP3A4
反应物种	Hu, Ms, Rat
应用	ICC/IF, IHC-P, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	CYP3A4
抗原物种	Human
抗原	Recombinantprotein of human CYP3A4 (a.a. 244-503).
偶联标记	Un-conjugated
別名	CYP3A4; Cytochrome P450 Family 3 Subfamily A Member 4; CYP3A3; Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 4; Cytochrome P450, Family 3, Subfamily A, Polypeptide 4; Albendazole Monooxygenase (Sulfoxide-Forming); 1,4-Cineole 2-Exo-Monooxygenase; 1,8-Cineole 2-Exo-Monooxygenase; Cholesterol 25-Hydroxylase; Albendazole Sulfoxidase; Quinine 3-Monooxygenase; Cytochrome P450 NF-25; Cytochrome P450-PCN1; Cytochrome P450 3A4; Cytochrome P450 3A3; Cytochrome P450 HLp; Nifedipine Oxidase; EC 1.14.14.1; CYPIIIA3; CYPIIIA4; Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 3; Taurochenodeoxycholate 6-Alpha-Hydroxylase; Glucocorticoid-Inducible P450; P450-III, Steroid Inducible; EC 1.14.14.56; EC 1.14.14.73; EC 1.14.14.55; P450PCN1; P450C3; CYP3A; NF-25; VDDR3; CP33; CP34; HLP

应用说明

应用建议

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 1576 Human CYP3A4 Swiss-port # P08684 Human Cytochrome P450 3A4
基因名称	CYP3A4
全名	Cytochrome P450 Family 3 Subfamily A Member 4
背景介绍	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2020]
生物功能	Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D3).[UniProt]
细胞定位	Endoplasmic reticulum, Membrane, Microsome.[UniProt]
预测分子量	57 kDa
翻译后修饰	Ubl conjugation

检测图片 (4)

ARG44590 anti-CYP3A4 antibody ICC/IF image
Immunofluorescence: HeLastained with ARG44590 anti-CYP3A4 antibody at 1:100 dilution.
ARG44590 anti-CYP3A4 antibody WB image
Western blot: 293F cells transfected with CYP3A4stained with ARG44590 anti-CYP3A4 antibody at 1:1000 dilution.
ARG44590 anti-CYP3A4 antibody IHC-P image
Immunohistochemistry: Rat ovary stained with ARG44590 anti-CYP3A4 antibody at 1:100 dilution.
ARG44590 anti-CYP3A4 antibody IHC-P image
Immunohistochemistry: Mouse liver stained with ARG44590 anti-CYP3A4 antibody at 1:100 dilution.

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