anti-CYTH1 / Cytohesin 1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG43272
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CYTH1 / Cytohesin 1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CYTH1 / Cytohesin 1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-70 of Human CYTH1 / Cytohesin 1 (NP_004753.1). |
| 偶联标记 | Un-conjugated |
| 別名 | PH, SEC7 and coiled-coil domain-containing protein 1; B2-1; Cytohesin-1; CYTOHESIN-1; SEC7 homolog B2-1; SEC7; D17S811E; PSCD1 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse brain | ||||||
| 实际分子量 | ~ 46 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CYTH1 |
| 全名 | cytohesin 1 |
| 背景介绍 | The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| 生物功能 | Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. [UniProt] |
| 细胞定位 | Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol. Cell junction, tight junction. Cell junction, adherens junction. Note=Colocalized with TJP1 during epithelial polarization. [UniProt] |
| 预测分子量 | 46 kDa |
检测图片 (2)
ARG43272 anti-CYTH1 / Cytohesin 1 antibody ICC/IF image
Immunofluorescence: L929 cells stained with ARG43272 anti-CYTH1 / Cytohesin 1 antibody at 1:100 dilution.
ARG43272 anti-CYTH1 / Cytohesin 1 antibody WB image
Western blot: 25 µg of Mouse brain lysate stained with ARG43272 anti-CYTH1 / Cytohesin 1 antibody at 1:1000 dilution.
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