anti-Cytokeratin (pan) antibody [C-11] (FITC)
![anti-Cytokeratin (pan) antibody [C-11] (FITC)](/upload/image/products/ARG54232_FACS_1_201117_210_205.jpg)
![anti-Cytokeratin (pan) antibody [C-11] (FITC)](/upload/image/products/ARG54232_FACS_1_201117.jpg)
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CAT.NO. : ARG54232
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Product Details
概述
| 产品描述 | FITC-conjugated Mouse Monoclonal antibody [C-11] recognizes Cytokeratin (pan) |
|---|---|
| 反应物种 | Hu, Ms, Rat, Mamm |
| 应用 | FACS |
| 特异性 | The clone C-11 reacts with Cytokeratin peptides 4, 5, 6, 8, 10, 13, 18. Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | C-11 |
| 同位型 | IgG1 |
| 靶点名称 | Cytokeratin (pan) |
| 抗原物种 | Human |
| 抗原 | Keratin-enriched preparation from human epidermoid carcinoma cell line A431. |
| 偶联标记 | FITC |
| 別名 | Keratin, type I cytoskeletal 18; Cytokeratin-18; K18; CK-18; Cell proliferation-inducing gene 46 protein; Keratin-18; CYK18 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC. |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KRT18 |
| 全名 | keratin 18, type I |
| 背景介绍 | Cytokeratins are a subfamily of intermediate filaments and characterized by remarkable biochemical diversity. Cytokeratins are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families. |
| 生物功能 | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. [UniProt] |
| 研究领域 | Controls and Markers antibody; Signaling Transduction antibody |
| 预测分子量 | 48 kDa |
| 翻译后修饰 | Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7. O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation. |
检测图片 (1)
ARG54232 anti-Cytokeratin (pan) antibody [C-11] (FITC) FACS image
Flow Cytometry: Separation of HeLa cells (red-filled) from human peripheral whole blood (black-dashed). Cells were stained with ARG54232 anti-Cytokeratin (pan) antibody [C-11] (FITC) at 3 µg/ml dilution.
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