anti-Desmoplakin I+II antibody [DP-2.15]
![anti-Desmoplakin I+II antibody [DP-2.15]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
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- 克隆:
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- 靶点名称:
- 抗原物种:
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CAT.NO. : ARG23200
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [DP-2.15] recognizes Desmoplakin DPI and DPII Mouse anti Desmoplakin 1/2 antibody, clone DP-2. 15 recognizes both desmoplakin 1 and 2 from stratified epithelia, simple epithelia including glands, urothelium, thymic reticular epithelium, hepatocytes, intercalated disks of myocardium and arachnoid cells of meninges. Mouse anti Desmoplakin 1/2 antibody, clone DP-2. 15 can be used for the detection of primary and metastatic carcinomas. Mouse anti Desmoplakin 1/2 antibody, clone DP-2. 15 recognizes the N terminus of the rod domain of desmoplakin ( Bornslaeger et al. 1996). |
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| 反应物种 | Hu, Ms, Rat, Bov, Chk |
| 应用 | ICC/IF, IHC-Fr, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | DP-2.15 |
| 同位型 | IgG1 |
| 靶点名称 | Desmoplakin I+II |
| 抗原物种 | Human |
| 抗原 | Native Bovine desmoplakin 1 and 2 purified from Bovine snout desmosomes. |
| 偶联标记 | Un-conjugated |
| 別名 | 250/210 kDa paraneoplastic pemphigus antigen; Desmoplakin; DP; DPII; DCWHKTA; DPI |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
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| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS and 0.09% Sodium azide. |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DSP |
| 全名 | desmoplakin |
| 背景介绍 | Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008] |
| 生物功能 | Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. [UniProt] |
| 预测分子量 | 332 kDa |
| 翻译后修饰 | Ser-2849 is probably phosphorylated by a cAMP-dependent protein kinase. Phosphorylation on Ser-2849 probably affects its association with epidermal, simple cytokeratins and VIM intermediate filaments. [UniProt] |
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