Anti-Detyrosinated alpha-Tubulin Rabbit Monoclonal Antibody [Clone RM444], 31-1335-00
![Anti-Detyrosinated alpha-Tubulin Rabbit Monoclonal Antibody [Clone RM444], 31-1335-00](/upload/image/products/RM444_Fig1_WB_dTyr-tubulin.png)
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CAT.NO. : 31-1335-00
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Product Details
Product Details
| Product Name | Anti-Detyrosinated alpha-Tubulin Rabbit Monoclonal Antibody, Clone RM444 |
| Product Description | Rabbit monoclonal to Detyrosinated alpha-Tubulin. |
| Catalog No. | 31-1335-00 |
| Clone Name | RM444 |
| Product Data Sheet | Anti-Detyrosinated alpha-Tubulin Rabbit Monoclonal Antibody Data Sheet RM444 |
| Specificity | RM444 reacts to detyrosinated alpha-Tubulin, a PTM of α-tubulin where the C-terminal tyrosine residue has been cleaved. |
| Immunogen | A peptide corresponding to detyrosinated alpha-Tubulin |
| Application | WB, ICC |
| Species Reactivity | Human |
| Conjugate | None |
| Intended Use | Research Use Only |
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Properties
| Form | Liquid |
| Storage Instructions | Store at -20.0°C |
| Stability | Stable for 1 Year at -20.0°C from date of receipt |
| Storage Buffer | 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide |
| Volume/Item Size | 100 µL |
| Purity | Protein A affinity purified from an animal origin–free culture supernatant |
| Clone Type | Monoclonal |
| Isotype | Rabbit IgG |
| Usage | WB: 1:1000 -1:2000 dilution; ICC/IF: 1:100 - 1:200 dilution. |
| References | Yang Y, et al. Microtubule detyrosination by VASH1/SVBP is regulated by the conformational state of tubulin in the lattice. Curr Biol. 2023 Oct 9;33(19):4111-4123.IF: 9.2 Q1. PMID: 37716348. Hotta T, et al. Mechanistic Analysis of CCP1 in Generating ΔC2 α-Tubulin in Mammalian Cells and Photoreceptor Neurons. Biomolecules. 2023 Feb 12;13(2):357.IF: 5.5 Q1. PMID: 36830726. Mathias TJ, et al. Tubulin Carboxypeptidase Activity Promotes Focal Gelatin Degradation in Breast Tumor Cells and Induces Apoptosis in Breast Epithelial Cells That Is Overcome by Oncogenic Signaling. Cancers (Basel). 2022 Mar 28;14(7):1707. IF: 5.2 Q2. PMID: 35406479. |
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Product Images
| Western Blot analysis of HeLa, U2OS, and CHL-1 cell lysates using anti-Detyrosinated alpha-Tubulin rabbit monoclonal |
 | Immunocytochemistry of CHL-1 using anti-Detyrosinated alpha-Tubulin rabbit monoclonal antibody (Clone RM444) at a 1:200 dilution (pink), anti-alpha-Tubulin (green) antibody, and DAPI (blue). Bar: 20 μm. |
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