anti-DFFB / DFF40 / CAD antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG54342
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DFFB / DFF40 / CAD |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 特异性 | This antibody recognizes human, mouse, and rat DFFB / DFF40 / CAD (40 kDa). |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DFFB / DFF40 / CAD |
| 抗原物种 | Mouse |
| 抗原 | Peptide corresponding to aa. 147-164 near the center of mouse DFFB / DFF40 / CAD (accession no. NP_031885). The sequence differs from human DFFB / DFF40 / CAD by two amino acids. |
| 偶联标记 | Un-conjugated |
| Protein Full name | DNA fragmentation factor subunit beta |
| 別名 | Caspase-activated DNase; DFF40; DFF-40; Caspase-activated deoxyribonuclease; DNA fragmentation factor 40 kDa subunit; Caspase-activated nuclease; CPAN; DNA fragmentation factor subunit beta; DFF2; CAD |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | K562 and Jurkat |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Immunoaffinity chroma-tography |
| 缓冲液 | PBS (pH 7.4) and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Dffb |
| 全名 | DNA fragmentation factor, beta subunit |
| 背景介绍 | Cell death signals are transduced by death domain-containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse Dnase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxy-ribonuclease). The human homologue of mouse CAD was more recently identified and termed CPAN, DFF40, and human CAD. DFF45/ICAD is the inhibitory protein of DFF40/CAD with which it forms complexes. Upon cleavage by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of DFF40/CAD is, which causes DNA degradation, is the hallmark of apoptotic cell death. |
| 生物功能 | Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. [UniProt] |
| 细胞定位 | Cytoplasm, Nucleus [uniprot] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody; Metabolism antibody |
| 预测分子量 | 39 kDa |
检测图片 (2)
ARG54342 anti-DFFB / DFF40 / CAD antibody ICC/IF image
Immunofluorescence: K562 cells stained with ARG54342 anti-DFFB / DFF40 / CAD antibody at 20 μg/ml dilution.
ARG54342 anti-DFFB / DFF40 / CAD antibody WB image
Western blot: H:HeLa; K:K562; J:Jurkat; R:Raji stained with ARG54342 anti-DFFB / DFF40 / CAD antibody at 1 μg/ml dilution.
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