anti-DMD / Dystrophin antibody [MANDYS8]
![anti-DMD / Dystrophin antibody [MANDYS8]](/upload/image/products/mouse_skeletal_muscle_210_205.jpg)
![anti-DMD / Dystrophin antibody [MANDYS8]](/upload/image/products/rat_skeletal_muscle.jpg)
![anti-DMD / Dystrophin antibody [MANDYS8]](/upload/image/products/Mouse_cardiac_muscle.jpg)
![anti-DMD / Dystrophin antibody [MANDYS8]](/upload/image/products/mouse_skeletal_muscle.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
-
Brand:
CAT.NO. : ARG41559
US＄ Please choose
US＄ Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [MANDYS8] recognizes DMD / Dystrophin |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | MANDYS8 |
| 同位型 | IgG2b |
| 靶点名称 | DMD / Dystrophin |
| 抗原物种 | Human |
| 抗原 | Recombinant Human DMD / Dystrophin fragment. |
| 偶联标记 | Un-conjugated |
| 別名 | BMD; CMD3B; DXS270; DXS272; MRX85; Dystrophin; DXS164; DXS239; DXS206; DXS142; DXS230; DXS269; DXS268 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Unpurified. |
| 缓冲液 | Mouse ascites fluid, 1.2% Sodium acetate, 0.01% Sodium azide and 2% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 2% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DMD |
| 全名 | dystrophin |
| 背景介绍 | The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix. [provided by RefSeq, Jul 2008] |
| 生物功能 | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. [UniProt] |
| 细胞定位 | Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane. Note=In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs). In adult muscle, NMJ localization depends upon ANK2 presence, but not in newborn animals. [UniProt] |
| 预测分子量 | 427 kDa |
检测图片 (3)
ARG41559 anti-DMD / Dystrophin antibody [MANDYS8] WB image
Western blot: Rat skeletal muscle stained with ARG41559 anti-DMD / Dystrophin antibody [MANDYS8] at 1 μg/mL dilution.
ARG41559 anti-DMD / Dystrophin antibody [MANDYS8] IHC-P image
Immunohistochemistry: Mouse cardiac muscle stained with ARG41559 anti-DMD / Dystrophin antibody [MANDYS8] at 2 μg/mL dilution.
ARG41559 anti-DMD / Dystrophin antibody [MANDYS8] WB image
Western blot: Mouse skeletal muscle stained with ARG41559 anti-DMD / Dystrophin antibody [MANDYS8] at 1 μg/mL dilution.
New Products
