anti-DMRT1 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes DMRT1
  • 反应物种: Hu, Ms, Rat
  • 预测物种: Hm
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: DMRT1
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG58524
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes DMRT1
反应物种Hu, Ms, Rat
预测物种Hm
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称DMRT1
抗原物种Human
抗原Synthetic peptide corresponding to a sequence at the N-terminus of Human DMRT1 (98-128aa RDCQCKKCNLIAERQRVMAAQVALRRQQAQE), different from the related Mouse sequence by one amino acid.
偶联标记Un-conjugated
別名DMT1; DM domain expressed in testis protein 1; Doublesex- and mab-3-related transcription factor 1; CT154
应用说明
应用建议
应用推荐稀释比
IHC-P0.5 - 1 µg/ml
WB0.1 - 0.5 µg/ml
应用说明IHC-P: Antigen Retrieval: By heat mediation.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA.
抗菌剂0.05% Sodium azide
稳定剂5% BSA
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 1761 Human DMRT1

GeneID: 50796 Mouse DMRT1

Swiss-port # Q9QZ59 Mouse Doublesex- and mab-3-related transcription factor 1

Swiss-port # Q9Y5R6 Human Doublesex- and mab-3-related transcription factor 1

基因名称DMRT1
全名doublesex and mab-3 related transcription factor 1
背景介绍This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]
生物功能Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). [UniProt]
细胞定位Nucleus. [UniProt]
预测分子量39 kDa
检测图片 (2)
  • ARG58524 anti-DMRT1 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human testis stained with ARG58524 anti-DMRT1 antibody.

  • ARG58524 anti-DMRT1 antibody WB image

    Western blot: 50 µg of Rat testis, 50 µg of Mouse testis, 50 µg of Rat brain, 50 µg of Mouse brain and 40 µg of U87 whole cell lysates stained with ARG58524 anti-DMRT1 antibody at 0.5 µg/ml dilution.

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