anti-DOK1 / p62 Dok antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes DOK1 / p62 Dok
  • 反应物种: Hu, Ms, Rat
  • 应用: ICC/IF, IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: DOK1 / p62 Dok
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 1-280 of Human DOK1 / p62 Dok (NP_001372.1).
  • Brand:
CAT.NO. : ARG42609
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes DOK1 / p62 Dok
反应物种Hu, Ms, Rat
应用ICC/IF, IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称DOK1 / p62 Dok
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 1-280 of Human DOK1 / p62 Dok (NP_001372.1).
偶联标记Un-conjugated
別名dok; p62; P62DOK; Docking protein 1; pp62; Downstream of tyrosine kinase 1
应用说明
应用建议
应用推荐稀释比
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
WB1:1000 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 13448 Mouse DOK1

GeneID: 1796 Human DOK1

GeneID: 312477 Rat DOK1

基因名称DOK1
全名docking protein 1, 62kDa (downstream of tyrosine kinase 1)
背景介绍The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
生物功能DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. [UniProt]
细胞定位Isoform 1: Cytoplasm. Nucleus. Isoform 3: Cytoplasm, perinuclear region. [UniProt]
预测分子量52 kDa
翻译后修饰Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS. [UniProt]
检测图片 (1)
  • ARG42609 anti-DOK1 / p62 Dok antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human gastric cancer tissue stained with ARG42609 anti-DOK1 / p62 Dok antibody at 1:100 dilution.

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