anti-Drebrin antibody [DBN-N-03] (PE)
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CAT.NO. : ARG54239
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Product Details
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [DBN-N-03] recognizes Drebrin |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The clone DBN-N-03 recognizes drebrin, an approximately 100-125 kDa regulator of actin cytoskeleton. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | DBN-N-03 |
| 同位型 | IgG2b |
| 靶点名称 | Drebrin |
| 抗原物种 | Human |
| 抗原 | Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326) |
| 偶联标记 | PE |
| 別名 | Developmentally-regulated brain protein; D0S117E; Drebrin |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | DBN1 |
| 全名 | drebrin 1 |
| 背景介绍 | Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spinesof neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse. |
| 生物功能 | Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. [UniProt] |
| 研究领域 | Cancer antibody; Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 71 kDa |
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