anti-DUSP3 antibody [9E6]

CAT.NO. : ARG57052

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Size:

50 μl

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Mouse Monoclonal antibody [9E6] recognizes DUSP3
反应物种	Hu
应用	WB
宿主	Mouse
克隆	Monoclonal
克隆号	9E6
同位型	IgG2b, kappa
靶点名称	DUSP3
抗原物种	Human
抗原	Recombinant fragment around aa. 1-185 of Human DUSP3.
偶联标记	Un-conjugated
別名	EC 3.1.3.16; Vaccinia H1-related phosphatase; Dual specificity protein phosphatase 3; EC 3.1.3.48; VHR; Dual specificity protein phosphatase VHR

应用说明

应用建议

应用	推荐稀释比
WB	1:3000

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purification with Protein A.
缓冲液	PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	10% Glycerol
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 1845 Human DUSP3 Swiss-port # P51452 Human Dual specificity protein phosphatase 3
基因名称	DUSP3
全名	dual specificity phosphatase 3
背景介绍	The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
生物功能	Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. [UniProt]
预测分子量	20 kDa

检测图片 (1)

ARG57052 anti-DUSP3 antibody [9E6] WB image
Western blot: 40 µg of 1) HeLa cell lysate, 2) HepG2 cell lysate, 3) Jurkat cell lysate, 4) MCF7 cell lysate, 5) 293T cell lysate, 6) U87MG cell lysate, 7) K562 cell lysate stained with ARG57052 anti-DUSP3 antibody [9E6] at 1:3000.

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