anti-DUSP5 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG59576
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DUSP5 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DUSP5 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-280 of Human DUSP5 (NP_004424.3). |
| 偶联标记 | Un-conjugated |
| 別名 | ERT; Epithelium-specific Ets transcription factor 1; Epithelial-restricted with serine box; ESE-1; ESX; E74-like factor 3; EPR-1; Epithelium-restricted Ets protein ESX; ETS-related transcription factor Elf-3 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | A549 | ||||||
| 实际分子量 | 42 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ELF3 |
| 全名 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
| 生物功能 | Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). [UniProt] |
| 细胞定位 | Cytoplasm. Nucleus. Note=Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism. [UniProt] |
| 预测分子量 | 41 kDa |
检测图片 (2)
ARG59576 anti-DUSP5 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat kidney stained with ARG59576 anti-DUSP5 antibody at 1:200 dilution.
ARG59576 anti-DUSP5 antibody WB image
Western blot: 25 µg of A549 cell lysate stained with ARG59576 anti-DUSP5 antibody at 1:1000 dilution.
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