anti-DUSP6 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes DUSP6
  • 反应物种: Hu, Ms, Rat
  • 应用: FACS, ICC/IF, IHC-P, IP, WB
  • 特异性: This antibody detects endogenous levels of total DUSP6.
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: DUSP6
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG57530
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes DUSP6
反应物种Hu, Ms, Rat
应用FACS, ICC/IF, IHC-P, IP, WB
特异性This antibody detects endogenous levels of total DUSP6.
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称DUSP6
抗原物种Human
抗原Synthetic peptide of Human DUSP6.
偶联标记Un-conjugated
別名Dual specificity protein phosphatase PYST1; MKP-3; MAP kinase phosphatase 3; MKP3; EC 3.1.3.16; PYST1; Dual specificity protein phosphatase 6; Mitogen-activated protein kinase phosphatase 3; EC 3.1.3.48; HH19
应用说明
应用建议
应用推荐稀释比
FACS1:50
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
IP1:50
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照NIH/3T3
实际分子量~ 38 kDa
属性
形式Liquid
纯化Purified by affinity chromatography.
缓冲液PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 116663 Rat DUSP6

GeneID: 1848 Human DUSP6

GeneID: 67603 Mouse DUSP6

基因名称DUSP6
全名dual specificity phosphatase 6
背景介绍The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
生物功能Inactivates MAP kinases. Has a specificity for the ERK family. [UniProt]
细胞定位Nucleus
预测分子量42 kDa
检测图片 (2)
  • ARG57530 anti-DUSP6 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human thyroid stained with ARG57530 anti-DUSP6 antibody.

  • ARG57530 anti-DUSP6 antibody WB image

    Western blot: NIH/3T3 cell lysate stained with ARG57530 anti-DUSP6 antibody.

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