anti-DYNLL1 / PIN antibody [13C9]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [13C9] recognizes DYNLL1 / PIN
  • 反应物种: Hu
  • 应用: WB
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: 13C9
  • 同位型: IgG2b, kappa
  • 靶点名称: DYNLL1 / PIN
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG57056
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Product Details
概述
产品描述Mouse Monoclonal antibody [13C9] recognizes DYNLL1 / PIN
反应物种Hu
应用WB
宿主Mouse
克隆Monoclonal
克隆号13C9
同位型IgG2b, kappa
靶点名称DYNLL1 / PIN
抗原物种Human
抗原Recombinant fragment corresponding to aa. 1-89 of Human DYNLL1 / PIN.
偶联标记Un-conjugated
別名LC8a; Dynein light chain 1, cytoplasmic; PIN; DNCLC1; Protein inhibitor of neuronal nitric oxide synthase; LC8; DLC8; 8 kDa dynein light chain; DLC1; DNCL1; Dynein light chain LC8-type 1; hdlc1
应用说明
应用建议
应用推荐稀释比
WBAssay-dependent
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein A.
缓冲液PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂10% Glycerol
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 8655 Human DYNLL1

Swiss-port # P63167 Human Dynein light chain 1, cytoplasmic

基因名称DYNLL1
全名dynein, light chain, LC8-type 1
背景介绍Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
生物功能Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.

Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.

Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.

Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity. [UniProt]
预测分子量10 kDa
翻译后修饰Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro.
检测图片 (1)
  • ARG57056 anti-DYNLL1 / PIN antibody [13C9] WB image

    Western blot: 40 µg of 1) HeLa, 2) A549, 3) 293T and 4) HepG2 cell lysates stained with ARG57056 anti-DYNLL1 / PIN antibody [13C9] at 1:1000 dilution.

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