anti-DYRK1B antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG54847
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes DYRK1B |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | DYRK1B |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 561-589 (C-terminus) of Human DYRK1B. |
| 偶联标记 | Un-conjugated |
| 別名 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B; MIRK; Minibrain-related kinase; EC 2.7.12.1; AOMS3; Mirk protein kinase |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse kidney |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9Y463 Human Dual specificity tyrosine-phosphorylation-regulated kinase 1B Swiss-port # Q9Z188 Mouse Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
|---|---|
| 基因名称 | DYRK1B |
| 全名 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B |
| 背景介绍 | This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] |
| 生物功能 | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC). [UniProt] |
| 细胞定位 | Nucleus. |
| 研究领域 | Cancer antibody |
| 预测分子量 | 69 kDa |
| 翻译后修饰 | Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization. |
检测图片 (1)
ARG54847 anti-DYRK1B antibody WB image
Western blot: Mouse kidney lysate stained with ARG54847 anti-DYRK1B antibody.
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