anti-EIF2AK4 / GCN2 phospho (Thr899) antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG59715
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes EIF2AK4 / GCN2 phospho (Thr899) |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 特异性 | Recognizes endogenous levels of EIF2AK4 / GCN2 phospho (Thr899) protein. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | EIF2AK4 / GCN2 |
| 抗原物种 | Human |
| 抗原 | Phosphospecific peptide around Thr899 of Human EIF2AK4 / GCN2. |
| 偶联标记 | Un-conjugated |
| 別名 | EC 2.7.11.1; GCN2; GCN2-like protein; PVOD2; Eukaryotic translation initiation factor 2-alpha kinase 4 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | ~ 250 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9P2K8 Human Eukaryotic translation initiation factor 2-alpha kinase 4 |
|---|---|
| 基因名称 | EIF2AK4 |
| 全名 | eukaryotic translation initiation factor 2 alpha kinase 4 |
| 背景介绍 | This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014] |
| 生物功能 | Can phosphorylate the alpha subunit of EIF2 and may mediate translational control. [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 187 kDa |
| 翻译后修饰 | Autophosphorylated; autophosphorylation on Thr-899 is increased upon amino acid starvation and in UV irradiation cells and inhibited in presence of IMPACT. [UniProt] |
检测图片 (1)
ARG59715 anti-EIF2AK4 / GCN2 phospho (Thr899) antibody WB image
Western blot: HeLa cells untreated (left) or treated with Calyculin (right). Cell lysates were stained with ARG59715 anti-EIF2AK4 / GCN2 phospho (Thr899) antibody.
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