anti-ENaC alpha antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG22200
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ENaC alpha |
|---|---|
| 反应物种 | Ms, Rat, Xenopus laevis |
| 应用 | ICC/IF, IHC-P, WB |
| 特异性 | Detects ~85kDa. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ENaC alpha |
| 抗原物种 | Rat |
| 抗原 | Synthetic peptide around aa. 46-68 (N-temrinus) of Rat ENaC Alpha |
| 偶联标记 | Un-conjugated |
| 別名 | ENaCalpha; ENaCa; Epithelial Na; Amiloride-sensitive sodium channel subunit alpha; ENaCA; SCNEA; Alpha-ENaC; BESC2; Nonvoltage-gated sodium channel 1 subunit alpha; Alpha-NaCH; SCNN1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.09% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Scnn1a |
| 全名 | sodium channel, non-voltage-gated 1 alpha subunit |
| 背景介绍 | Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009] |
| 生物功能 | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. [UniProt] |
| 细胞定位 | Apical cell membrane |
| 预测分子量 | 76 kDa |
| 翻译后修饰 | Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation. ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation. N-glycosylated. |
检测图片 (3)
ARG22200 anti-ENaC alpha antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Rat kidney tissue stained with ARG22200 anti-ENaC alpha antibody (green) at 1:25 dilution for 1 hour at RT. Phalloidin-Alexa Fluor 633 (red) for actin staining. DAPI (blue) for nuclear staining.
ARG22200 anti-ENaC alpha antibody WB image
Western blot: Rat kidney tissue lysates stained with ARG22200 anti-ENaC alpha antibody at 1:1000 dilution.
ARG22200 anti-ENaC alpha antibody WB image
Western blot: Mouse kidney tissue lysates stained with ARG22200 anti-ENaC alpha antibody.
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