anti-Factor V Heavy chain antibody [B10]
![anti-Factor V Heavy chain antibody [B10]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
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CAT.NO. : ARG54560
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [B10] recognizes Factor V Heavy chain |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | This antibody reacts with the activation C peptide (mw ~150,000) in the heavy chain of thrombin-cleaved human Factor V. KD = 1.15 x 10-10 mol/L. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | B10 |
| 同位型 | IgG1 |
| 靶点名称 | Factor V Heavy chain |
| 抗原物种 | Human |
| 抗原 | Purified human Factor V. |
| 偶联标记 | Un-conjugated |
| 別名 | FVL; Activated protein C cofactor; PCCF; Coagulation factor V; THPH2; Proaccelerin, labile factor; RPRGL1 |
应用说明
| 应用说明 | This antibody may be used in ELISA, immunohistochemistry, and autoradiography. Other applications are under investigation. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G-purified |
| 缓冲液 | PBS (pH 7.4) |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | F5 |
| 全名 | coagulation factor V (proaccelerin, labile factor) |
| 背景介绍 | This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008] |
| 生物功能 | Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody |
| 预测分子量 | 252 kDa |
| 翻译后修饰 | Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity. Activated protein C inactivates factor V and factor Va by proteolytic degradation. Phosphorylated by FAM20C in the extracellular medium. |
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