anti-FBXW7 antibody [SP237]

CAT.NO. : ARG53014

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Size:

100 μl

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Rabbit Monoclonal antibody [SP237] recognizes FBXW7
反应物种	Hu
应用	FACS, IHC-P
宿主	Rabbit
克隆	Monoclonal
克隆号	SP237
同位型	IgG
靶点名称	FBXW7
抗原物种	Human
抗原	Synthetic peptide derived from the internal region of human FBXW7 protein.
偶联标记	Un-conjugated
別名	AGO; F-box protein FBX30; hCdc4; FBW7; FBW6; F-box/WD repeat-containing protein 7; SEL-10; hAgo; FBX30; SEL10; FBXO30; F-box and WD-40 domain-containing protein 7; CDC4; FBXW6; Archipelago homolog

应用说明

应用建议

应用	推荐稀释比
FACS	Assay-Dependent
IHC-P	1:100

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

阳性对照

Endometrial Adenocarcinoma, Lung Squamous Cell Carcinoma

属性

形式	Liquid
纯化	Purified by protein A/G
缓冲液	PBS (pH 7.6), 1% BSA and
抗菌剂
稳定剂	1% BSA
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 55294 Human FBXW7 Swiss-port # Q969H0 Human F-box/WD repeat-containing protein 7
背景介绍	F-box/WD repeat-containing protein 7 (Fbxw7) is part of an ubiquitin-protein ligase complex. The complex ubiquitinates and degrades several important oncogenes such as mTOR, MYC, AURKA, JUN, and NOTCH1. Fbxw7 cooperates with PTEN for tumor suppression and is widely expressed in many normal tissues. The loss of fbxw7 is associated with malignant progression in a variety of tumors, including carcinoma of colorectum, lung, stomach, bile duct, endometrium, pancreas, breast and glioblastoma.
细胞定位	Cytoplasm, Nucleus, Nucleolus
研究领域	Cancer antibody; Cell Biology and Cellular Response antibody
预测分子量	80 kDa
翻译后修饰	Phosphorylation at Thr-205 promotes interaction with PIN1, leading to disrupt FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation (PubMed:22608923). Ubiquitinated: autoubiquitinates following phosphorylation at Thr-205 and subsequent interaction with PIN1. Ubiquitination leads to its degradation (PubMed:22608923).

检测图片 (1)

ARG53014 anti-FBXW7 antibody [SP237] IHC-P image
Immunohistochemistry: Human Endometrial Adenocarcinoma stained with FBXW7 antibody [SP237] (ARG53014)

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