anti-Filamin antibody [FLMN01 (PM6/317)]
![anti-Filamin antibody [FLMN01 (PM6/317)]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
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CAT.NO. : ARG62492
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [FLMN01 (PM6/317)] recognizes Filamin |
|---|---|
| 反应物种 | Hu, Ms, Rat, Chk, Gpig, Rb |
| 应用 | ELISA, IHC, IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | FLMN01 (PM6/317) |
| 同位型 | IgG1 |
| 靶点名称 | Filamin |
| 抗原 | Platelet filamin |
| 偶联标记 | Un-conjugated |
| 別名 | Endothelial actin-binding protein; ABP-280; XMVD; ABPX; Actin-binding protein 280; FLN1; MNS; OPD1; XLVD; OPD2; OPD; Non-muscle filamin; CSBS; Filamin-A; FLN-A; FLN; NHBP; Filamin-1; FMD; Alpha-filamin; CVD1 |
应用说明
| 应用说明 | WB: 1-2 ug/ml ELISA 1/100 - 1/2000 IHC: 1/10-1/500 IHC-P: 1-2 ug/ml * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G purified |
| 缓冲液 | 10mM PBS (pH 7.4), 0.2% BSA and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 0.2% BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | FLNA |
| 全名 | filamin A, alpha |
| 背景介绍 | The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009] |
| 生物功能 | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. [UniProt] |
| 细胞定位 | Cytoplasm; cell cortex |
| 研究领域 | Signaling Transduction antibody |
| 预测分子量 | 281 kDa |
| 翻译后修饰 | Phosphorylation at Ser-2152 is negatively regulated by the autoinhibited conformation of filamin repeats 19-21. Ligand binding induces a conformational switch triggering phosphorylation at Ser-2152 by PKA. Phosphorylation extent changes in response to cell activation. Polyubiquitination in the CH1 domain by a SCF-like complex containing ASB2 leads to proteasomal degradation. Prior dissociation from actin may be required to expose the target lysines (PubMed:24052262). Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome (PubMed:26766444). |
参考文献
克隆号文献
Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin.
WB / Human
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