anti-FOXM1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG57595
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes FOXM1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ChIP, ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | FOXM1 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human FOXM1. |
| 偶联标记 | Un-conjugated |
| 別名 | MPP-2; TRIDENT; MPHOSPH2; Forkhead-related protein FKHL16; HFH11; HNF-3/fork-head homolog 11; MPP2; FKHL16; HFH-11; Transcription factor Trident; INS-1; M-phase phosphoprotein 2; HNF-3; FOXM1B; Hepatocyte nuclear factor 3 forkhead homolog 11; Winged-helix factor from INS-1 cells; Forkhead box protein M1; PIG29; MPM-2 reactive phosphoprotein 2 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | HeLa | ||||||||
| 实际分子量 | 108 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | FOXM1 |
| 全名 | forkhead box M1 |
| 背景介绍 | The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] |
| 生物功能 | Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. [UniProt] |
| 预测分子量 | 84 kDa |
| 翻译后修饰 | Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators. [UniProt] |
检测图片 (1)
ARG57595 anti-FOXM1 antibody WB image
Western blot: 25 µg of HeLa cell lysate stained with ARG57595 anti-FOXM1 antibody at 1:1000 dilution.
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