anti-FZD9 / Frizzled 9 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG66638
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes FZD9 / Frizzled 9 |
|---|---|
| 反应物种 | Hu, Mk |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | FZD9 / Frizzled 9 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide between aa. 520-600 of Human FZD9 / Frizzled 9. |
| 偶联标记 | Un-conjugated |
| 別名 | Frizzled-9; Fz-9; FZD3; CD349; FzE6; CD antigen CD349; hFz9 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | ~ 65 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.5% BSA |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | FZD9 |
| 全名 | frizzled class receptor 9 |
| 背景介绍 | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. Note=Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane. [UniProt] |
| 预测分子量 | 64 kDa |
| 翻译后修饰 | Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. [UniProt] |
检测图片 (4)
ARG66638 anti-FZD9 / Frizzled 9 antibody ICC/IF image
Immunofluorescence: A549 cells stained with ARG66638 anti-FZD9 / Frizzled 9 antibody. The picture on the right is blocked with the synthetic peptide.
ARG66638 anti-FZD9 / Frizzled 9 antibody WB image
Western blot: HUVEC lysate stained with ARG66638 anti-FZD9 / Frizzled 9 antibody.
ARG66638 anti-FZD9 / Frizzled 9 antibody WB image
Western blot: HUVEC, COLO and COS cell lysates stained with ARG66638 anti-FZD9 / Frizzled 9 antibody. The lane on the right is blocked with the synthetic peptide.
ARG66638 anti-FZD9 / Frizzled 9 antibody WB image
Western blot: Jurkat cell lysate stained with ARG66638 anti-FZD9 / Frizzled 9 antibody.
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