anti-GABAA Receptor alpha 1 antibody [S95-35]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [S95-35] recognizes GABAA Receptor alpha 1
  • 反应物种: Hu, Ms, Rat
  • 应用: ICC/IF, IHC, WB
  • 特异性: Detects ~55kDa. No cross-reactivity against GABA-A-R-Alpha 2 or -Alpha3.
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: S95-35
  • 同位型: IgG2a
  • 靶点名称: GABAA Receptor alpha 1
  • Brand:
CAT.NO. : ARG22236
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Product Details
概述
产品描述Mouse Monoclonal antibody [S95-35] recognizes GABAA Receptor alpha 1
反应物种Hu, Ms, Rat
应用ICC/IF, IHC, WB
特异性Detects ~55kDa. No cross-reactivity against GABA-A-R-Alpha 2 or -Alpha3.
宿主Mouse
克隆Monoclonal
克隆号S95-35
同位型IgG2a
靶点名称GABAA Receptor alpha 1
抗原物种Human
抗原Fusion protein around aa. 355-394 of Human GABAA Receptor alpha 1
偶联标记Un-conjugated
別名A; EJM; EIEE19; EJM5; Gamma-aminobutyric acid receptor subunit alpha-1; ECA4; GABA
应用说明
应用建议
应用推荐稀释比
ICC/IF1:100
IHC1:1000
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein G.
缓冲液PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol
抗菌剂0.09% Sodium azide
稳定剂50% Glycerol
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 14394 Mouse GABRA1

GeneID: 2554 Human GABRA1

GeneID: 29705 Rat GABRA1

基因名称Gabra1
全名gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
背景介绍This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
生物功能Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity). [UniProt]
细胞定位Cell Junction, Cell membrane, postsynaptic cell membrane, Synapse
预测分子量52 kDa
检测图片 (1)
  • ARG22236 anti-GABAA Receptor alpha 1 antibody [S95-35] WB image

    Western blot: Human cell line lysates stained with ARG22236 anti-GABAA Receptor alpha 1 antibody [S95-35] at 1:1000 dilution.

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