anti-GABAA Receptor alpha 2 antibody
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Key features and details
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- 抗原物种:
- 抗原:
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CAT.NO. : ARG52288
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GABAA Receptor alpha 2 |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GABAA Receptor alpha 2 |
| 抗原物种 | Rat |
| 抗原 | Fusion protein from the cytoplasmic loop of the alpha 2 subunit |
| 偶联标记 | Un-conjugated |
| 別名 | A; Gamma-aminobutyric acid receptor subunit alpha-2; GABA |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | Specific for the ~51k α2-subunit of the GABAA receptor in Western blots. Labeling is absent in 2-subunit knockout animals. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P26048 Mouse Gamma-aminobutyric acid receptor subunit alpha-2 |
|---|---|
| 背景介绍 | Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six s, four s and four s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for - and -subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a -subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different - subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003). |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 51 kDa |
检测图片 (1)
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ARG52288 anti-GABAA Receptor alpha 2 antibody WB image
Western blot: mouse brain lysates from wild type (Control) and α2-knockout (α2-K/O) animals stained with ARG52288 anti-GABAA Receptor alpha 2 antibody showing specific immunolabeling of the ~51k α2-subunit of the GABAA-R. The labeling was absent from a lysate prepared from α2-knockout animals.
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