anti-GABAA Receptor delta antibody
Key features and details
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Brand:
CAT.NO. : ARG52299
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GABAA Receptor delta |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | ICC/IF, IHC-Fr, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GABAA Receptor delta |
| 抗原物种 | Rat |
| 抗原 | Fusion protein from the N-terminal region of the delta subunit |
| 偶联标记 | Un-conjugated |
| 別名 | A; EJM7; GEFSP5; Gamma-aminobutyric acid receptor subunit delta; EIG10; GABA |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | Specific for the ~52k δ-subunit of the GABAA receptor. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P18506 Rat Gamma-aminobutyric acid receptor subunit delta Swiss-port # P22933 Mouse Gamma-aminobutyric acid receptor subunit delta |
|---|---|
| 基因名称 | GABRD |
| 全名 | gamma-aminobutyric acid (GABA) A receptor, delta |
| 背景介绍 | Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, co-expression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α- subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003). More recently there have been a number of studies demonstrating that the δ-subunit of the receptor may affect subunit assembly (Korpi et al., 2002) and may also confer differential sensitivity to neurosteroids and to ethanol (Wallner et al., 2003; Wohlfarth et al., 2002). |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 51 kDa |
检测图片 (1)
ARG52299 anti-GABAA Receptor delta antibody WB image
Western blot: Mouse cerebellar lysates from wild type (control) and delta knockout (delta K/O) animals showing specific immunolabeling of the ~52 kDa delta-subtunit of the GABAA-R in the wild type but not in the delta K/O animals when stained with ARG52299 anti-GABAA Receptor delta antibody.
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