anti-GABAA Receptor gamma 2 phospho (Ser327) antibody
Key features and details
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- 抗原:
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Brand:
CAT.NO. : ARG52303
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GABAA Receptor gamma 2 phospho (Ser327) |
|---|---|
| 反应物种 | Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GABAA Receptor gamma 2 |
| 抗原物种 | Rat |
| 抗原 | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser327 conjugated to KLH |
| 偶联标记 | Un-conjugated |
| 別名 | A; CAE2; ECA2; GEFSP3; Gamma-aminobutyric acid receptor subunit gamma-2; GABA |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | Specific for ~45k GABAA receptor γ2 subunit phosphorylated at Ser327. Immunolabeling of the GABAA band is completely blocked by λ-phosphatase treatment. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P18508 Rat Gamma-aminobutyric acid receptor subunit gamma-2 |
|---|---|
| 基因名称 | GABRG2 |
| 全名 | gamma-aminobutyric acid (GABA) A receptor, gamma 2 |
| 背景介绍 | Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. It has recently been suggested that PKCΕ regulates the sensitivity of GABAA α1β2γ2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of γ2 (Qi et al., 2007) |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 54 kDa |
| 翻译后修饰 | Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability. |
检测图片 (1)
ARG52303 anti-GABAA Receptor gamma 2 phospho (Ser327) antibody WB image
Western blot: Rat cortex showing specific immunolabeling of the ~45 kDa GABA γ 2 protein phosphorylated at Ser327 (control) stained with ARG52303 anti-GABAA Receptor gamma 2 phospho (Ser327) antibody. Immunolabeling is blocked by the phosphopeptide (Peptide) used as antigen but not by the corresponding dephosphopeptide.
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