anti-GADD45 alpha antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes GADD45A
  • 反应物种: Hu
  • 预测物种: Bov
  • 应用: FACS, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: GADD45 alpha
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG54931
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes GADD45A
反应物种Hu
预测物种Bov
应用FACS, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称GADD45 alpha
抗原物种Human
抗原KLH-conjugated synthetic peptide corresponding to aa. 1-30 (N-terminus) of Human GADD45 alpha.
偶联标记Un-conjugated
別名Growth arrest and DNA damage-inducible protein GADD45 alpha; DDIT1; GADD45; DNA damage-inducible transcript 1 protein; DDIT-1
应用说明
应用建议
应用推荐稀释比
FACS1:10 - 1:50
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Y79
属性
形式Liquid
纯化This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
缓冲液PBS and 0.09% (W/V) Sodium azide
抗菌剂0.09% (W/V) Sodium azide
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 1647 Human GADD45A

Swiss-port # P24522 Human Growth arrest and DNA damage-inducible protein GADD45 alpha

基因名称GADD45A
全名growth arrest and DNA-damage-inducible, alpha
背景介绍This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]
生物功能In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. [UniProt]
细胞定位Nucleus.
研究领域Gene Regulation antibody
预测分子量18 kDa
检测图片 (2)
  • ARG54931 anti-GADD45 alpha antibody WB image

    Western blot: 35 µg of Y79 cell lysate stained with ARG54931 anti-GADD45 alpha antibody.

  • ARG54931 anti-GADD45 alpha antibody FACS image

    Flow Cytometry: K562 cells stained with ARG54931 anti-GADD45 alpha antibody (right histogram) or without primary antibody control (left histogram), followed by incubation with FITC labelled secondary antibody.

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