anti-Galectin 3 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
Product Details
| 产品描述 | Rabbit Polyclonal antibody recognizes Galectin 3 |
|---|---|
| 反应物种 | Hu, Ms, Rat, Pig |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Galectin 3 |
| 抗原物种 | Human |
| 抗原 | Full length recombinant Galectin 3 expressed in and purified from E. coli |
| 偶联标记 | Un-conjugated |
| 別名 | Laminin-binding protein; Gal-3; L-31; GALBP; Galactoside-binding protein; MAC2; GAL3; GALIG; Mac-2 antigen; CBP 35; Galectin-3; CBP35; Galactose-specific lectin 3; IgE-binding protein; L31; 35 kDa lectin; Carbohydrate-binding protein 35; Lectin L-29 |
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 30 kDa |
| 形式 | Liquid |
|---|---|
| 纯化 | Unpurified |
| 缓冲液 | Serum and 5mM Sodium azide. |
| 抗菌剂 | 5mM Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | |
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| 基因名称 | LGALS3 |
| 全名 | lectin, galactoside-binding, soluble, 3 |
| 背景介绍 | This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014] |
| 生物功能 | Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. [UniProt] |
| 预测分子量 | 26 kDa |
ARG11061 anti-Galectin 3 antibody ICC/IF image
Immunofluorescence: Cortical neuron-glial cell culture from E20 Rat stained with ARG11061 anti-Galectin 3 antibody (green) at 1:2000 dilution, and costained with mouse mAb to GFAP (red) at 1:2000 dilution. The blue is Hoechst staining of nuclear DNA.
Certain glial cells express only galectin-3 protein, and appear green, while the majority of glial cells and astrocytes produces GFAP protein and so appear red, a few cells that express both protein appear orange-yellow.
ARG11061 anti-Galectin 3 antibody ICC/IF image
Immunofluorescence: Cortical neuron-glial cells from E20 Rat stained with ARG11061 anti-Galectin 3 antibody (green) at 1:2000 dilution and costained with ARG10719 anti-MAP2 antibody [4H5] (red) at 1:2000 dilution. Hoechst (blue) for nuclear staining.
The Galectin 3 antibody produces strong staining of certain glial cells, while MAP2 antibody labels dendrites and perikarya of mature neurons.
ARG11061 anti-Galectin 3 antibody WB image
Western blot: Mouse heart, Mouse liver, Mouse kidney, Mouse lung, Rat cortical neuron-glial primary cell culture and Pig spinal cord lysates stained with ARG11061 anti-Galectin 3 antibody at 1:5000 dilution.
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