anti-Glucose 6 phosphate isomerase antibody
Key features and details
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- 预测物种:
- 应用:
- 宿主:
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- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG55368
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Glucose 6 phosphate isomerase |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 预测物种 | Mk |
| 应用 | FACS, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Glucose 6 phosphate isomerase |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 445-473 (C-terminus) of Human Glucose 6 phosphate isomerase. |
| 偶联标记 | Un-conjugated |
| 別名 | PHI; SA36; GPI; SA-36; EC 5.3.1.9; Autocrine motility factor; Neuroleukin; GNPI; PGI; Sperm antigen 36; Phosphoglucose isomerase; Glucose-6-phosphate isomerase; NLK; AMF; Phosphohexose isomerase |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse liver |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GPI |
| 全名 | glucose-6-phosphate isomerase |
| 背景介绍 | This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| 生物功能 | Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. [UniProt] |
| 细胞定位 | Cytoplasm. Secreted |
| 研究领域 | Cancer antibody; Immune System antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 63 kDa |
| 翻译后修饰 | Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway. ISGylated. |
检测图片 (2)
ARG55368 anti-Glucose 6 phosphate isomerase antibody WB image
Western blot: 35 µg of Mouse liver lysate stained with ARG55368 anti-Glucose 6 phosphate isomerase antibody at 1:1000 dilution.
ARG55368 anti-Glucose 6 phosphate isomerase antibody FACS image
Flow Cytometry: Ramos cells stained with ARG55368 anti-Glucose 6 phosphate isomerase antibody (right histogram) or without primary antibody control (left histogram), followed by incubation with FITC labelled secondary antibody.
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