anti-Glutamine Synthetase antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG55691
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Glutamine Synthetase |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 预测物种 | Bov, Chk, Mk, Pig |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Glutamine Synthetase |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 70-96 (N-terminus) of Human Glutamine Synthetase. |
| 偶联标记 | Un-conjugated |
| 別名 | GS; PIG43; Glutamate decarboxylase; EC 6.3.1.2; PIG59; Glutamine synthetase; Glutamate--ammonia ligase; GLNS; EC 4.1.1.15 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Jurkat |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GLUL |
| 全名 | glutamate-ammonia ligase |
| 背景介绍 | The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| 生物功能 | This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts. [UniProt] |
| 细胞定位 | Cytoplasm. Mitochondrion. |
| 产品亮点 | Related products: Glutamine Synthetase antibodies; Anti-Rabbit IgG secondary antibodies; Related news: Switching identity, the potential of regenerative medicine? |
| 预测分子量 | 42 kDa |
| 翻译后修饰 | Ubiquitinated by ZNRF1. |
检测图片 (2)
ARG55691 anti-Glutamine Synthetase antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver tissue stained with ARG55691 anti-Glutamine Synthetase antibody at 1:25 dilution.
ARG55691 anti-Glutamine Synthetase antibody WB image
Western blot: 20 µg of Jurkat cell lysate stained with ARG55691 anti-Glutamine Synthetase antibody at 1:1000 dilution.
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