anti-Glycine Receptor antibody
Key features and details
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- 靶点名称:
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- 抗原:
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Brand:
CAT.NO. : ARG52321
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Glycine Receptor |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | IHC, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Glycine Receptor |
| 抗原物种 | Rat |
| 抗原 | Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH |
| 偶联标记 | Un-conjugated |
| 別名 | Glycine receptor 48 kDa subunit; STHE; HKPX1; Glycine receptor strychnine-binding subunit; Glycine receptor subunit alpha-1 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | Specific for the ~48k α1- and α2-subunits of the glycine receptor in Western blots of Rat spinal cord and brain stem and in cell extracts. Immunolabeling blocked by preadsorption of antibody with the peptide immunogen. Does not recognize other glycine receptor subunits. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Powder |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | lyophilized |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GLRA1 |
| 全名 | glycine receptor, alpha 1 |
| 背景介绍 | Glycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission (Schofield et al., 2003). The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin (Fischer et al., 2000). The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins (Beckstead et al., 2001; Mihic et al., 1997). These receptors have also been extremely useful in studies of synaptic clustering of receptors (Craig and Lichtman, 2001). The glycine receptor may also act in concert with an NMDAR subunit to form an excitatory receptor (Chatterton et al., 2002). |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 53 kDa |
检测图片 (1)
ARG52321 anti-Glycine Receptor antibody WB image
Western blot: Rat spinal cord and hippocampal lysates showing specific immunolabeling of the ~48 kDa glycine receptor in spinal cord stained with ARG52321 anti-Glycine Receptor antibody.
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