anti-Glycogen Synthase 1 phospho (Ser641) antibody
Key features and details
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- 反应物种:
- 应用:
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- 克隆:
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- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG40298
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Glycogen Synthase 1 phospho (Ser641) |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Glycogen Synthase 1 |
| 抗原物种 | Human |
| 抗原 | Phosphospecific peptide around Ser641 of Human Glycogen Synthase 1. |
| 偶联标记 | Un-conjugated |
| 別名 | GSY; GYS; EC 2.4.1.11; Glycogen [starch] synthase, muscle |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | HeLa | ||||||||||
| 实际分子量 | ~ 88 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4),0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P13807 Human Glycogen [starch] synthase, muscle Swiss-port # Q9Z1E4 Mouse Glycogen [starch] synthase, muscle |
|---|---|
| 基因名称 | GYS1 |
| 全名 | glycogen synthase 1 (muscle) |
| 背景介绍 | The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
| 生物功能 | Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. [UniProt] |
| 预测分子量 | 84 kDa |
| 翻译后修饰 | Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Phosphorylated at Ser-641 by DYRK2, leading to inactivation (By similarity). Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme. [UniProt] |
检测图片 (1)
ARG40298 anti-Glycogen Synthase 1 phospho (Ser641) antibody WB image
Western blot: HeLa cell lysate stained with ARG40298 anti-Glycogen Synthase 1 phospho (Ser641) antibody.
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