anti-GNAI3 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG58987
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GNAI3 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GNAI3 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-354 of Human GNAI3 (NP_006487.1). |
| 偶联标记 | Un-conjugated |
| 別名 | 87U6; ARCND1; Guanine nucleotide-binding protein G(k) subunit alpha; G(i) alpha-3 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | MCF7 | ||||||||
| 实际分子量 | 45 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P08754 Human Guanine nucleotide-binding protein G(k) subunit alpha Swiss-port # Q9DC51 Mouse Guanine nucleotide-binding protein G(k) subunit alpha |
|---|---|
| 基因名称 | GNAI3 |
| 全名 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 |
| 背景介绍 | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012] |
| 生物功能 | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. [UniProt] |
| 细胞定位 | Cell membrane, Cytoplasm, Lipid-anchor, Membrane, centrosome, cytoskeleton, microtubule organizing center. [UniProt] |
| 预测分子量 | 41 kDa |
| 翻译后修饰 | (Microbial infection) Deamidated at Gln-204 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA. [UniProt] |
检测图片 (2)
ARG58987 anti-GNAI3 antibody WB image
Western blot: 25 µg of MCF7 cell lysate stained with ARG58987 anti-GNAI3 antibody at 1:1000 dilution.
ARG58987 anti-GNAI3 antibody IP image
Immunoprecipitation: 200 µg extracts of MCF7 cells were immunoprecipitated and stained with ARG58987 anti-GNAI3 antibody at 1:1000 dilution.
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