anti-GNE antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
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- 克隆:
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- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG42857
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GNE |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | ICC/IF, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GNE |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human GNE. |
| 偶联标记 | Un-conjugated |
| 別名 | DMRV; GLCNE; ManAc kinase; IBM2; NM; Uae1; Uridine diphosphate-N-acetylglucosamine-2-epimerase; hydrolyzing; UDP-GlcNAc-2-epimerase; EC 3.2.1.183; EC 2.7.1.60; Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | HeLa | ||||||||
| 实际分子量 | ~ 75 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | 50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 浓度 | Batch dependent |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # O35826 Rat Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase Swiss-port # Q9Y223 Human Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinas |
|---|---|
| 基因名称 | GNE |
| 全名 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
| 背景介绍 | The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| 生物功能 | Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 79 kDa |
| 翻译后修饰 | Phosphorylated by PKC. [UniProt] |
检测图片 (1)
ARG42857 anti-GNE antibody WB image
Western blot: HeLa cell lysate stained with ARG42857 anti-GNE antibody at 1:1000 dilution.
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