anti-GSAP / PION antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原:
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Brand:
CAT.NO. : ARG54667
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GSAP / PION |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ELISA, ICC/IF, IHC, WB |
| 特异性 | Multiple isoforms of PION are known to exist. PION antibody is predicted to not cross-react with other F-box protein family members. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GSAP / PION |
| 抗原 | Synthetic peptide (19 aa) within aa. 770-820 of Human PION. |
| 偶联标记 | Un-conjugated |
| 別名 | Protein pigeon homolog; GSAP-16K; GSAP; PION; Gamma-secretase-activating protein |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | EL4 Cell Lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # A4D1B5 Human Gamma-secretase-activating protein Swiss-port # Q3TCV3 Mouse Gamma-secretase-activating protein |
|---|---|
| 基因名称 | GSAP |
| 全名 | gamma-secretase activating protein |
| 背景介绍 | PION Antibody: Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer's disease patient's brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer's disease. | |
| 研究领域 | Developmental Biology antibody; Gene Regulation antibody; Neuroscience antibody |
| 预测分子量 | 98 kDa |
| 翻译后修饰 | The protein is first synthesized as a holoprotein form of 98 kDa and rapidly processed into the gamma-secretase-activating protein 16 kDa C-terminal form, which constitutes the predominant form. |
检测图片 (3)
ARG54667 anti-PION antibody ICC/IF image
Immunofluorescence: human brain cells stained with ARG54667 anti-PION antibody at 20 μg/ml.
ARG54667 anti-PION antibody IHC image
Immunohistochemistry: human brain tissue stained with ARG54667 anti-PION antibody at 5 μg/ml.
ARG54667 anti-PION antibody WB image
Western blot: EL4 cell lysate stained with ARG54667 anti-PION antibody at 0.25 μg/ml in (A) the absence and (B) the presence of blocking peptide.
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