anti-GSK3 beta phospho (Ser9) antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes GSK3 beta phospho (Ser9)
  • 反应物种: Rat
  • 预测物种: Hu, Ms, Bov, Chk, Dog, NHuPrm, Xenopus laevis, Zfsh
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: GSK3 beta
  • 抗原物种: Rat
  • Brand:
CAT.NO. : ARG52322
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes GSK3 beta phospho (Ser9)
反应物种Rat
预测物种Hu, Ms, Bov, Chk, Dog, NHuPrm, Xenopus laevis, Zfsh
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称GSK3 beta
抗原物种Rat
抗原Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser9 conjugated to KLH
偶联标记Un-conjugated
別名EC 2.7.11.26; EC 2.7.11.1; GSK-3 beta; Glycogen synthase kinase-3 beta; Serine/threonine-protein kinase GSK3B
应用说明
应用建议
应用推荐稀释比
WB1:1,000
应用说明Specific for the ~46k GSK3β protein phosphorylated at Ser9 . Also weakly labels the ~51k GSK3α band due to the high degree of homology between the 2 subunits. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity Purified
缓冲液10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol
稳定剂0.1 mg/ml BSA, 50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 84027 Rat GSK3B

Swiss-port # P18266 Rat Glycogen synthase kinase-3 beta

基因名称GSK3B
全名glycogen synthase kinase 3 beta
背景介绍Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that is involved in the regulation of many signaling pathways. To date, 2 isoforms have been identified: GSK3α and GSK3β. Specifically, GSK3β has been shown to play a key inhibitory role in both the insulin and Wnt signaling pathways (Papkoff and Aikawa 1998). It has been suggested that Ser9 phosphorylation underlies the inhibition of GSK3β by insulin (Sutherland et al., 1993).
研究领域Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody
预测分子量47 kDa
翻译后修饰Phosphorylated by AKT1 and ILK1. Upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3B, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-216 (PubMed:25169422). Inactivated by phosphorylation at Ser-9 (Probable).
Mono-ADP-ribosylation by PARP10 negatively regulates kinase activity.
检测图片 (1)
  • ARG52322 anti-GSK3 beta phospho (Ser9) antibody WB image

    Western blot: Rat cortex lysate showing phospho-specific immunolabeling of the ~46k GSK3p protein phosphorylated at Ser 9 stained with ARG52322 anti-GSK3 beta phospho (Ser9) antibody.

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